Projects

Projects

Research projects I have led or contributed to.

Ongoing2026–
Met4Metab: Standardisation of targeted and untargeted metabolomic methods for clinical diagnosis
Funder
European Partnership on Metrology (EURAMET)
Role
Researcher
Metabolomics, which can measure hundreds of small molecules in blood or urine at once, is one of the most powerful tools for personalised medicine, yet its results are not comparable between laboratories and so cannot move from research into hospital laboratories. Met4Metab is building the metrological infrastructure to make metabolomics results traceable to the SI. For targeted methods it is developing robot-prepared calibration solutions containing more than 50 metabolites together, with reference measurement procedures; for untargeted methods, calibration strategies based on "beacon molecules" identified by machine learning, and three new matrix reference materials. Coordinated by PTB with 19 organisations, the project started in July 2026.
Project page →
Completed2021–2024
Improved metrology for quantitative MRI
Funder
EMPIR (EURAMET)
Role
Researcher
The same patient's MR image can look different depending on the scanner it was taken on, so results from different hospitals cannot be compared directly. iMet-MRI laid the metrological foundation needed to turn MRI from a device that produces pictures into one that makes reliable measurements. SI-traceable phantom materials, standardised measurement procedures and uncertainty analyses were developed for all five measurands: T1, T2, fat fraction, iron content and diffusion. Before the project, only NIST could offer traceability anywhere in the world, and only for three of them. The methods were tested on scanners from the three major manufacturers, from 0.55 to 7 T, in a multi-site study across four countries. By the end of the project, the IEC had accepted that new standards are needed for quantitative MRI.
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Completed2019–2022
Quantitative MR-based imaging of physical biomarkers
Funder
EMPIR (EURAMET)
Role
Researcher
More than 30 million MRI scans are performed in Europe every year, yet results still rely mostly on a specialist's visual interpretation. QUIERO set out to turn two emerging techniques, Electrical Properties Tomography (EPT) and Magnetic Resonance Fingerprinting (MRF), into reliable diagnostic tools in which every pixel measures a tissue property together with its uncertainty. The project developed tissue-mimicking phantoms, released its algorithms as open source, and identified detection thresholds for brain and heart diseases in two clinical studies. Its EPTlib library was recognised by ISMRM as the first EPT software publicly available on the internet.
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Ongoing2018–
Benzoic acid calorific value reference material for calorimeters
Role
Researcher
Production and certification of a benzoic acid thermal value reference material for calorimeters (CRM project).
Ongoing2012–
National marker system for fuels
Role
Researcher
Government project on the development and continuous updating of the national marker system for fuels.
Completed2018–2021
Amino acid and neurotoxic amino acid reference materials for lentil analysis
Role
Researcher
Development and certification of certified reference materials and quality control materials for amino acid and neurotoxic amino acid measurements in lentil analysis by food control laboratories (CRM project).
Completed2014–2017
Amino acid and organic acid reference materials for clinical laboratories and newborn screening
Role
Researcher
Development and certification of amino acid and organic acid quality control materials and certified reference materials for routine clinical laboratory analysis and newborn screening (CRM project).
Completed2014–2017
KEY-VOCs: Metrology for VOC indicators in air pollution and climate change
Funder
EMRP (EURAMET)
Role
Researcher
Volatile organic compounds (VOCs) affect both the quality of the air we breathe and the climate, yet they are notoriously hard to measure: they occur at parts-per-billion or even parts-per-trillion levels, and they stick to and react with surfaces. The EMRP ENV56 KEY-VOCs project brought together nine European national metrology institutes and the European Commission's Joint Research Centre to develop traceable reference gas standards for these measurements. For the first time, cylinder gas standards and portable calibrators became available for priority oxygenated VOCs and monoterpenes in atmospheric monitoring; reference materials were prepared for indoor air, and low-cost benzene sensors were systematically tested. The results fed into the World Meteorological Organization's global monitoring network and European standards.
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Completed2012–2014
Aflatoxins in dried figs reference material
Role
Researcher
Production and certification of a certified reference material for aflatoxins B1, B2, G1, G2 and total aflatoxin in dried figs (CRM project).
Completed2012–2014
Chloramphenicol primary calibrant reference material
Role
Researcher
Production and certification of a chloramphenicol primary calibrant certified reference material (CRM project).
Completed2010–2011
Adamantane-substituted cyclophosphazenes
Funder
TÜBİTAK
Role
Researcher
Synthesis and investigation of the thermal properties of adamantane-derivative substituted cyclophosphazenes.
Completed2008–2009
Reactions of mono-substituted aminophosphazenes with thiophenol
Funder
Gebze Technical University
Role
Researcher
Investigation of the reactions of mono-substituted aminophosphazenes with thiophenol.
Completed2007–2009
Chiral cyclophosphazene derivatives
Funder
TÜBİTAK
Role
Researcher
Synthesis of chiral cyclophosphazene derivatives, separation of their enantiomers and determination of their absolute configuration.
Completed2006–2008
Cyclophosphazene dimers from amine-containing cyclophosphazenes
Funder
TÜBİTAK
Role
Researcher
Obtaining cyclophosphazene dimers from amine-containing cyclophosphazenes and investigating their thermal properties.

Met4Metab: Standardisation of targeted and untargeted metabolomic methods for clinical diagnosis

Improved metrology for quantitative MRI

Quantitative MR-based imaging of physical biomarkers

Benzoic acid calorific value reference material for calorimeters

National marker system for fuels

Amino acid and neurotoxic amino acid reference materials for lentil analysis

Amino acid and organic acid reference materials for clinical laboratories and newborn screening

KEY-VOCs: Metrology for VOC indicators in air pollution and climate change

Aflatoxins in dried figs reference material

Chloramphenicol primary calibrant reference material

Adamantane-substituted cyclophosphazenes

Reactions of mono-substituted aminophosphazenes with thiophenol

Chiral cyclophosphazene derivatives

Cyclophosphazene dimers from amine-containing cyclophosphazenes